HuCAR T Day +28 results

On Day 28, Beau had a bone marrow biopsy and a lumbar puncture. These tests yield 4 test results:

1.) Review of cells in spinal fluid.

2.) Review of cells in bone marrow. a. Reviewed by pathologist under a microscope. b. Measured for minimal residual disease (MRD).

3.) Check for B-cell aplasia in the bone marrow (which indicates T-cell persistence)

4.) Bone marrow Next Generation Sequencing (NGS)- a sample of bone marrow is compared genetically to the Leukemia positive bone marrow sample from Jan 2019 diagnosis.

Results are slowly dribbling in:

1.) spinal fluid is 💫 CLEAR 💫

2.) a. Pathology review is 💫 CLEAR 💫 b. Still pending.

3.) B-cell aplasia in marrow- verified. This is good because last go round we already had 10% hematagone (immature b-cells) return at Day 28.

4.) Still pending

We are thankful for these results and eager to receive the rest.

That’s all for now. Xx